Interplay of Lipid Peroxidation, Chronic Inflammation, and Platelet Aggregation in the Pathogenesis of Human Diseases
DOI:
https://doi.org/10.17721/fujcV14I1P193-210Keywords:
lipid peroxidation, oxidative stress, chronic inflammation, platelet aggregationAbstract
Lipid peroxidation is a key manifestation of oxidative stress and an important mechanism of cellular injury. Excessive production of reactive oxygen species promotes membrane lipid oxidation and the accumulation of toxic lipid peroxidation products. Chronic inflammation further amplifies oxidative stress, creating a self-perpetuating cycle that promotes platelet activation, adhesion, and aggregation. Together, these processes represent closely interconnected pathogenic mechanisms contributing to endothelial dysfunction and the progression of chronic inflammatory diseases.
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