Chromone-3-carboxaldehyde and Fouramine-PY-Based CIMC Ligand: Synthesis, structural characterization and anticancer evaluation
DOI:
https://doi.org/10.17721/fujcV14I1P71-82Keywords:
Fouramine PY, chromone-3-carboxaldehyde, Schiff base ligand (CIMC), metal complexes, biological applications.Abstract
The Schiff base ligand (CIMC), derived from fouramine PY and chromone-3-carboxaldehyde, and its Co(II), Ni(II), Cu(II), Zn(II), Mn(II), and VO(II) complexes were synthesized and characterized using mass, FT-IR, UV-visible spectroscopy, powder X-ray diffraction, thermal analysis, CHN elemental analysis, and molar conductivity measurements. The ligand and its metal complexes were screened for biological activities by using two gram-positive and two gram-negative bacterial strains and three fungal strains. The free ligand exhibits inhibition zones 15 mm for S. aureus, 34 mm for B. subtilis, 39 mm for S. typhi and 19.5 mm for K. pneumonia. Among all the complexes, Cu(II), Zn(II), Mn(II), and VO(II) showed highest activity with inhibition zone of 15.5-18 mm for S. aureus, Mn(II) showed the highest zone of inhibition for B. subtilis and Co(II), Cu(II) showed the highest activity with an inhibition zone of 20 and 32 mm against K. pneumoniae. For the T. viride antifungal strain, free ligand showed zone of inhibition 23.5 mm, whereas Mn(II) and VO(II) showed the highest value 34 and 27.5 mm, which indicates superior activity of the complexes. The anticancer evaluation was screened against the human MCF-7 breast cancer cell line by using the MTT assay. The results showed that the free ligand exhibits a significant IC50 value of 28.23 µg/ml compared with the reference drug 5-FU (IC50 = 42.08), indicating enhanced anticancer potential.
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