Contribution of Systemic Inflammation to the Pathogenesis of Endothelial Dysfunction
DOI:
https://doi.org/10.17721/fujcV13I2P75-89Keywords:
inflammation, pathogenesis, endothelium, endothelial dysfunction, dyslipoproteinemiaAbstract
The study of the role of the endothelium in regulating physiological processes in the human body has been one of the most significant areas of medical science in recent decades. The vascular endothelium is a hormonally active tissue that regulates vascular tone by releasing vasodilatory and vasoconstrictor factors, modulating the contractile activity of smooth muscle cells. In various diseases, including inflammatory ones, the ability of endothelial cells to release relaxing factors is reduced, leading to the development of endothelial dysfunction, which, in turn, is a leading mechanism in the pathogenesis of the development and progression of cardiovascular diseases.
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