Risk Factors for the Health of the Population of an Industrial City and Their Impact on Regional Features of Inflammatory Diseases
DOI:
https://doi.org/10.17721/fujcV13I1P198-216Keywords:
health, inflammation, risk factors, immunobiological reactivity, industrial city, inflammatory diseases, regional featuresAbstract
The medical and social significance of inflammatory diseases in Ukraine is growing every year, which is associated with the deterioration of the ecological situation and the decrease in the immune response under the influence of adverse environmental factors. Acute inflammatory processes are increasingly taking a protracted course, and inflammation, having arisen evolutionarily as an adaptive reaction aimed at the formation of an immune response, due to the inconsistency of its control mechanisms leads to the development of chronic inflammatory and autoimmune diseases, therefore, it is necessary to systematize knowledge about the mechanisms and specifics of the inflammatory reaction under the influence of factors of various nature, to present their similarities and differences.
References
Ferrara P. Health Risk Factors, Prevention, and Inequalities. Medicina 2025;61(1):127. https://doi.org/10.3390/medicina61010127
Kudriawytzka AN, Karabach KS, Shandra V. General Risk Factors In The System Of Forming The Health Of The Population. Modern Engineering and Innovative Technologies 2024;2(31-02):3–6. https://doi.org/10.30890/2567-5273.2024-31-00-084
Brauer M, Roth G, Aravkin A, Zheng P, Abate K. Global burden and strength of evidence for 88 risk factors in 204 countries and 811 subnational locations, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021. The Lancet 2024;403(10440):2162-2203. https://doi.org/10.1016/s0140-6736(24)00933-4
Sokolovskaya I, Kryachok I, Chorna I, Semeniv I, Kotuza A, Hryhorieva N, Plakhotnik O, Zarytska V, Zhuravel V, Kmetyuk Y, Kondratiuk A. Influence of exogenous, physiological and factors of chronic inflammatory process on indicators of disturbances of adaptive processes of the person. French-Ukrainian Journal of Chemistry 2020;8(2):183-202. https://doi.org/10.17721/fujcv8i2p183-202
Sokolovskaya I, Kutsak A, Zarytska V, Nechiporenko V, Gordiyenko N, Siliavina Y, Horash K, Plakhotnik O. Investigation of aspects of the interaction of the indicators of lipid exchange, trombocitarian block of hemostasis, total body reactivity and their influence on the psychosomatic harmonization of the man in chronic inflammatory processes. French-Ukrainian Journal of Chemistry 2019;7(2):120-137. https://doi.org/10.17721/fujcv7i2p120-137
Netea M, Balkwill F, Chonchol M, Cominelli F, Donath M, Giamarellos-Bourboulis E, Golenbock D, Gresnigt M, Heneka M, Hoffman H, Hotchkiss R, Joosten L, Kastner D, Korte M, Latz E, Libby P, Mandrup-Poulsen T, Mantovani A, Mills K, Nowak K, O'Neill L, Pickkers P, van der Poll T, Ridker P, Schalkwijk J, Schwartz D, Siegmund B, Steer C, Tilg H, van der Meer J, van de Veerdonk F, Dinarello C. A guiding map for inflammation. Nature Immunology 2017;18(8):826-831. https://doi.org/10.1038/ni.3790
Chovatiya R, Medzhitov R. Stress, Inflammation, and Defense of Homeostasis. Molecular Cell 2014;54(2):281-288. https://doi.org/10.1016/j.molcel.2014.03.030
Medzhitov R. Inflammation 2010: New Adventures of an Old Flame. Cell 2010;140(6):771-776. https://doi.org/10.1016/j.cell.2010.03.006
Barton G. A calculated response: control of inflammation by the innate immune system. Journal of Clinical Investigation 2008;118(2):413-420. https://doi.org/10.1172/jci34431
Hajishengallis G, Reis E, Mastellos D, Ricklin D, Lambris J. Novel mechanisms and functions of complement. Nature Immunology 2017;18(12):1288-1298. https://doi.org/10.1038/ni.3858
Almeida L, Lochner M, Berod L, Sparwasser T. Metabolic pathways in T cell activation and lineage differentiation. Seminars in Immunology 2016;28(5):514-524. https://doi.org/10.1016/j.smim.2016.10.009
Goronzy J, Weyand C. Successful and Maladaptive T Cell Aging. Immunity 2017;46(3):364-378. https://doi.org/10.1016/j.immuni.2017.03.010
Li D, Wu M. Pattern recognition receptors in health and diseases. Signal Transduction and Targeted Therapy 2021;6(1). https://doi.org/10.1038/s41392-021-00687-0
Sokolovskaya I, Prybora N, Valentyna Nechyporenko V, Pozdniakova O, Hordiienko N, Nechyporenko K, Siliavina Y, Mavrin V, Kotuza A, Kliusov O, Kryachok I, Tytorenko I, Zub V, Yanitka L, Hordienko N, Kudinova M, Mamedli Z, Hordiienko L, Kmetyuk Y, Sprynchuk N. Assessment of the State of Platelet Haemostasis and Adhesive - Aggregation Properties of Platelets as a Factor of Increasing the Tendency to Thrombosis in Chronic Inflammation. French-Ukrainian Journal of Chemistry 2022;10(2):22-36. https://doi.org/10.17721/fujcv10i2p22-36
Hajishengallis G, Reis E, Mastellos D, Ricklin D, Lambris J. Novel mechanisms and functions of complement. Nature Immunology 2017;18(12):1288-1298. https://doi.org/10.1038/ni.3858
Abdesheikhi J, Sedghy F, Mahmoodi M, Fallah H, Ranjkesh M. Metabolic Regulation of T cell Activity: Implications for Metabolic-Based T-cell Therapies for Cancer. Iranian Biomedical Journal 2023;27(1):1-14. https://doi.org/10.52547/ibj.3811
Cheok Y, Lee C, Cheong H, Looi C, Wong W. Chronic Inflammatory Diseases at Secondary Sites Ensuing Urogenital or Pulmonary Chlamydia Infections. Microorganisms 2020;8(1):127. https://doi.org/10.3390/microorganisms8010127
Sokolovskaya I, Prybora N, Nechyporenko V, Pozdniakova O, Hordiienko N, Nechyporenko K, Siliavina Y, Serhata N, Mavrin V, Semeniv I, Kotuza A, Pokropyvnyi O, Ibrahimova O, Kryachok I, Tytorenko I, Yanitka L, Zarytska V, Bulanov V, Muz N, Kudinova M, Essandoh M. Peculiarities of the State of the Body's Immunoprotective Functions, Bacterioscopic and Cytological Studies in the Presence of a Chronic Inflammatory Process of the Reproductive System. French-Ukrainian Journal of Chemistry 2023;11(1):60-73. https://doi.org/10.17721/fujcv11i1p60-73
Ageitos J, Sánchez-Pérez A, Calo-Mata P, Villa T. Antimicrobial peptides (AMPs): Ancient compounds that represent novel weapons in the fight against bacteria. Biochemical Pharmacology 2017;133:117-138. https://doi.org/10.1016/j.bcp.2016.09.018
Rivera A, Siracusa M, Yap G, Gause W. Innate cell communication kick-starts pathogen-specific immunity. Nature Immunology 2016;17(4):356-363. https://doi.org/10.1038/ni.3375
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