Enantioselective Catalyzed Addition of Substituted Indens to Unsaturated Epoxides
DOI:
https://doi.org/10.17721/fujcV13I1P98-103Keywords:
substituted indenes, regioselectivity, enantioselectivity, unsaturated aromatic epoxides, (R)-1,1'-bi-2,2'-naphthotitanium diisopropoxideAbstract
Unsaturated aromatic epoxides can be regioselectively opened by substituted indenes in the presence of catalytic amounts of (R)-1,1'-bi-2,2'-naphthotitanium diisopropoxide (1 mol%). The reaction proceeds and enables the synthesis of (1R,2R)-2-(5-bromo-1H-inden-3-yl)-2-phenyl-1-[(prop-2-yn-1-yl)oxy]propan-1-ol with moderate yield and high enantioselectivity (ee up to 97%).
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