Ring closing metathesis strategies to isoxazole containing thiadiazepines
DOI:
https://doi.org/10.17721/fujcV7I1P104-112Keywords:
sulfamides, isoxazole, thiadiazepine, diallyl derivatives, ring closing metathesisAbstract
Cyclic sulfamides are attractive molecules with potential application in medical chemistry. It is known that thiadiazepine-containing derivatives demonstrate promising value in the development of protease inhibitors such as HIV protease, serine protease and metaloprotease. We demonstrate here a comfortable synthetic sequence to symmetric thiadiazepines containing isoxazole substitutents. The structure of the obtained substances was confirmed by 1H, 13C NMR spectroscopy.
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